Design, synthesis and biological evaluation of novel isoniazid derivatives with potent antitubercular activity
نویسندگان
چکیده
منابع مشابه
Mechanochemical Synthesis and Biological Evaluation of Novel Isoniazid Derivatives with Potent Antitubercular Activity.
A series of isoniazid derivatives bearing a phenolic or heteroaromatic coupled frame were obtained by mechanochemical means. Their pH stability and their structural (conformer/isomer) analysis were checked. The activity of prepared derivatives against Mycobacterium tuberculosis cell growth was evaluated. Some compounds such as phenolic hydrazine 1a and almost all heteroaromatic ones, especially...
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ژورنال
عنوان ژورنال: European Journal of Medicinal Chemistry
سال: 2014
ISSN: 0223-5234
DOI: 10.1016/j.ejmech.2014.04.077